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KMID : 0377519950200020123
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Chung-Ang Journal of Medicine
1995 Volume.20 No. 2 p.123 ~ p.138
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Study on Iron Status until Two Months of Life in Prematurity, Term Small for Gestational Age, Term Large for Gestational Age
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윤신원
임인석/김철하/이동근/최응상/유병훈
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Abstract
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The iron status of neonatal perioand shows variable changes dependent upon gestational age and birth weight.
In general, compared with TAGA(term appropriate for gestational age), prematurity has been known to have exacerbated from physiologic anemia and one of the possible contributable factor have been thought to be the lowered iron storage.
But the iron status of TSGA(term small for gestational age) and TLGA(term large for gestational age) in early few months of life has not been clearly known yet.
The purpose of this study was to compare the changes four groups.
The iron status of the newborn was assessed cord blood hemoglobin corrected reticulocyte count, iron, TIBC, ferritin in TAGA(n=20), TSGA(n=11), TLGA(n=22), and prematurity(n=50) that were admitted to the Department of Pediatrics, Chung-Ang
University
Hospital from June 1994 to February 1995. The follow up examinations were performed at 1. 2 months of postnatal period.
@ES The results are as follows:
@EN 1) Mean cord blood hemoglobin levels in TAGA, prematurity, TSGA, TLGA, at birth were 15.6±1.4 g/dl, 16.3±1.4 g/dl, 17.8±2.2 g/dl, 16.4±1.5g/dl. There was statistical significances between TAGA and other three groups(P<0.05).
2) Mean cord blood iron levels in TAGA, prematurity, TSGA, TLGA at birth were 229±48㎍/dl, 150±60㎍/dl, 194±14㎍/dl. But there was no statistical significances.
3) Mean cord blood TIBC levels in TAGA, prematurity, TSGA, TLGA at birth were 194±71㎍/dl, 210±60㎍/dl, 280±80㎍/dl, 304±96㎍/dl. There was statistical significance between TAGA and other three groups(P<0.05).
4) Mean cord blood ferritin levels in TAGA, prematurity, TSGA, TLGA at birth were 170±48ng/dl, 107±87ng/dl, 108±68ng/dl, 170±48ng/dl. There was statistical significances between TAGA and other three groups(P<0.05).
5) As a results of 2 months follow-up examination, the blood hemoglobin, corrected reticulocyte count, iron, ferritin levels were decreased and TIBC levels increased in all groups and compared with TAGA, there was significant differences the
othere
three groups(P<0.05).
In conclusion, blood hemoglobin, corrected reticulocyte count, iron, ferritin levels were significantly decreased and TIBC levels were significantly increased not only prematurity but also in TSGA, TLGA, so the marked impaired iron storage was
noted in
these groups in early few months of life.
Further studies need to assess the postnatal affect of prolonged iron redistribution on fetal tissue, to prevent the exacervated form or iron storage and metabolic derangement, we speculate that this particular group of infant may be candidates
for
early few months of life iron supplementation.
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